hy said on the 11th that it confirmed the preventive effect of HY2782, a patented probiotic strain it developed in-house, against intestinal inflammation and published a related paper in an SCI-level international journal.
The study focused on verifying the effects of HY2782 in the form of "postbiotics." Postbiotics are materials that use inactivated cells or their derived components. Although these microorganisms no longer proliferate, they can produce beneficial physiological effects in the body. hy said they are advantageous for commercialization because they offer excellent stability related to maintaining raw material quality.
hy researchers administered live HY2782 and heat-treated cells separately to animals in which colitis was induced. As a result, all test subjects showed ▲ suppression of weight loss ▲ recovery of colon length ▲ improvement in the disease activity index (DAI) ▲ reduction of colon tissue damage. Levels of inflammatory cytokines also decreased, showing an effect of suppressing the inflammatory response.
According to hy, the effect of protecting the intestinal barrier was also clear. The expression of genes related to the intestinal barrier that consolidate between intestinal epithelial cells recovered, and the function of the damaged intestinal mucosal barrier improved.
A hy official said, "This study scientifically demonstrates that HY2782 can provide preventive effects against intestinal inflammation and protect the intestinal barrier not only in its live state but also in the form of postbiotics," and added, "Going forward, hy will continue to elucidate the functionalities of strains in various forms through microbiome research."